tS=In public lectures, Prusiner has referred with some <b>asperity</b> to this early rejection of his work.<br><br>Jake evokes New York's <b>asperities</b>, along with the beauty of the seasons. &tQ=<b>Asperity</b> refers to:&tC=Disappointment|Harshness|Wry humor|Hurt feelings|Diffidence&cC=2&fB=<b>Asperity</b> refers to roughness, harshness, or severity as of surface, sound, or climate; to harshness or sharpness of temper, especially as shown in tone or manner. <b>Asperity</b> is pronounced ahs-PEHR-uh-tee.
